Cheesy Mexican Casserole – Easy, Crowd-Favorite Recipe

Some nights just call for a big, cozy, flavor-packed dinner that feels like a hug in a dish. That’s where this cheesy Mexican casserole comes in. It’s bold, creamy, crunchy, and bubbling with gooey cheese — everything you want after a long day, especially when comfort food needs to feed a crowd fast.

Why You’ll Love This Cheesy Mexican Casserole

A Family Favorite With Bold Flavors

This cheesy Mexican casserole isn’t just loaded with flavor — it brings people to the table. Savory ground beef, tangy tomato sauce, melty cheese, and crunchy Doritos create layers of texture and taste. It’s the kind of meal that wins over picky eaters and keeps everyone going back for seconds. I’ve even served it to guests who asked for the recipe before dessert.

Perfect for Make-Ahead Meals or Parties

You can prep it ahead, stash it in the fridge, and pop it in the oven when ready. It reheats like a dream and makes leftovers feel like a bonus. Whether you’re planning for a potluck, game night, or an easy weeknight dinner, this one’s a keeper.

Ingredients You’ll Need

Pantry Staples & Fresh Ingredients

Here’s what you’ll need for the cheesy Mexican casserole:

• 1 lb ground beef
• 1/2 cup chopped onion or 2 tbsp dried onion
• 1 clove garlic, minced
• 1 (16 oz) can refried beans
• 1 (10 oz) can cream of mushroom soup
• 1 (8 oz) can tomato sauce
• 1 (4 oz) can chopped green chilies
• 1 (9.75 oz) bag Doritos Nacho Cheese Chips
• 1½ cups Cheddar or Colby cheese, grated
• 1½ cups Monterrey Jack cheese, grated

Optional Add-Ins & Variations

If you want a little extra heat or depth, try these:

• 1 (10 oz) can tomatoes with green chilies
• Swap Doritos for tortilla chips
• Use only Cheddar if that’s what you have
• Sub ground turkey for beef if you prefer leaner

Step-by-Step: How to Make Cheesy Mexican Casserole

Brown the Meat and Aromatics

Start by browning the ground beef in a large skillet over medium heat. Add the chopped onion and minced garlic. Stir until soft and fragrant. Drain off the fat.

Mix in Sauces and Beans

Next, stir in the refried beans, cream of mushroom soup, tomato sauce, and green chilies. Mix until creamy and well combined. Set the pan aside.

Layer With Doritos and Cheese

Grease a 9×13-inch baking dish. Crush a layer of Doritos into the bottom. Spoon half the meat mixture over the chips. Sprinkle a generous layer of both cheeses.

Repeat with a second layer of chips, the rest of the meat mixture, and more cheese. If using, top with tomatoes and chilies. Add the final cheese layer last.

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Bake to Bubbly, Cheesy Perfection

Bake uncovered at 350°F for about 40 minutes. The top should be melted and golden. Let it cool slightly so it sets up — trust me, it tastes even better after a few minutes.

Best Type of Ground Beef for This Recipe

Flavor vs. Lean Options

I prefer 80/20 ground beef here for the flavor and richness. But you can absolutely go leaner if needed — just be sure to drain it well and maybe add a dash of taco seasoning to boost the taste.

Tips for Prepping Meat Ahead

Want to save time? Brown a double batch of beef and freeze half for next time. It makes busy weeknight dinners much easier and faster.

Helpful Tips and Shortcuts

Save Time With Pre-Cooked Ingredients

• Use pre-shredded cheese
• Opt for dried onion instead of fresh
• Grab pre-cooked ground beef from your freezer

Adjusting for Taste and Texture

Craving more crunch? Add extra chips just before serving. Like it spicy? Toss in jalapeños or hot sauce. This dish is super forgiving, so make it yours.

More Such Recipes

If you love this cheesy Mexican casserole, try pairing it with Mexican Street Corn Casserole – the perfect side for bold, cheesy meals or a lighter twist like Ground Beef Zucchini Casserole for a healthy twist on classic comfort.

For even more cozy dinners, check out Slow Cooker Cowboy Casserole packed with hearty flavors or Santa Fe Chicken – a zesty one-pan meal idea.

You can also find more inspiration on my Pinterest or come say hi on Facebook.

FAQs About Cheesy Mexican Casserole

Cheesy Mexican Casserole Recipe Card

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